专利名称：Vectors for regulating gene expression发明人：Shyam S. Mohapatra申请号：US10544146申请日：20040223
公开号：US20060239971A1公开日：20061026
摘要：The present invention pertains to vectors for regulating gene expression havingat least one gene expressing cassette and at least one gene suppressing cassette,wherein the gene expression cassette encodes a polypeptide of interest, and wherein thegene suppressing cassette encodes a short interfering RNA (siRNA) molecule thatreduces expression of a target gene by RNA interference. The present invention furtherincludes vectors that contain suppressor cassettes in conjunction with cassettesupregulating gene expression regulated by either a constitutive promoter, such as ageneral CMV promoter, or a tissue specific promoter. The present invention furtherincludes vectors that contain Dengue virus gene suppression cassettes. The presentinvention further includes pharmaceutical compositions containing such vectors, methodsof modulating the expression of genes in a host using such vectors, and method ofproducing such vectors.
申请人：Shyam S. Mohapatra
地址：Tampa FL US
国籍：US
更多信息请下载全文后查看
因篇幅问题不能全部显示，请点此查看更多更全内容