Asymmetric synthetic methods based on phase transf

专利名称：Asymmetric synthetic methods based on

phase transfer catalysis

发明人：Thomas C. Pochapsky,Christine Hofstetter申请号：US09902446申请日：20010710

公开号：US20020115896A1公开日：20020822

摘要：One aspect of the present invention relates to methods of asymmetricsynthesis, e.g., asymmetric hydride reductions of carbonyl groups, using a chiral, non-racemic phase transfer catalyst, a helper nucleophile, and a sterically bulky reagentnucleophile, e.g., an alkoxyhydride derived from a sacrificial ketone and a hydridereagent. Moreover, the sterically bulky reagent nucleophile may be generated in situ orprepared in a prior step. Another aspect of the present invention relates to chiral non-racemic phase transfer catalysts, and their use in the subject methods.

申请人：POCHAPSKY THOMAS C.,HOFSTETTER CHRISTINE

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